| 產(chǎn)品編號 | bsm-62861R |
| 英文名稱 | Phospho-GLUT4 (Ser488) Recombinant Rabbit mAb |
| 中文名稱 | 磷酸化葡萄糖轉(zhuǎn)運(yùn)蛋白4重組兔單抗 |
| 別 名 | insulin-responsive; Glucose transporter GLUT 4; Glucose transporter type 4; Glucose transporter type 4 insulin responsive; GLUT4; Insulin responsive glucose transporter type 4; SLC2A4; Solute carrier family 2 member 4. |
| 抗體來源 | Rabbit |
| 克隆類型 | Recombinant |
| 克 隆 號 | |
| 交叉反應(yīng) | Human,Mouse,Rat |
| 產(chǎn)品應(yīng)用 | WB=1:1000-1:2000
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 55 kDa |
| 檢測分子量 | 45 |
| 性 狀 | Liquid |
| 免 疫 原 | A synthesized peptide derived from human GLUT4 around the phosphorylation site of S488: HRTP-pS-LLE |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 10mM phosphate buffered saline(pH 7.4) with 150mM sodium chloride, 0.05% BSA, 0.02% Proclin300 and 50% glycerol. |
| 保存條件 | Store at 4℃ for short term. Store at -20℃ for long term. Avoid repeated freeze/thaw cycles. |
| 注意事項 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
Insulin-regulated facilitative glucose transporter, which plays a key role in removal of glucose from circulation. Response to insulin is regulated by its intracellular localization: in the absence of insulin, it is efficiently retained intracellularly within storage compartments in muscle and fat cells. Upon insulin stimulation, translocates from these compartments to the cell surface where it transports glucose from the extracellular milieu into the cell. SWISS: P14672 Gene ID: 6517 葡萄糖轉(zhuǎn)運(yùn)蛋白-4是一種十分重要的葡萄糖轉(zhuǎn)運(yùn)體,與胰島素抵抗和2型糖尿病密切相關(guān).葡萄糖轉(zhuǎn)運(yùn)蛋白4在細(xì)胞內(nèi)部和細(xì)胞膜之間循環(huán)流動.實現(xiàn)對葡萄糖的轉(zhuǎn)運(yùn)需要葡萄糖轉(zhuǎn)運(yùn)蛋白4自身的轉(zhuǎn)位和活化.葡萄糖轉(zhuǎn)運(yùn)蛋白4與肥胖、腫瘤相關(guān)聯(lián). GLUT-2和GLUT-4蛋白這兩個葡萄糖運(yùn)載體的研究對于糖尿病的胰島素釋放障礙和胰島素抵抗有重要意義. |
