| 產(chǎn)品編號(hào) | bsm-62883R |
| 英文名稱 | Galectin 3 Recombinant Rabbit mAb |
| 中文名稱 | 半乳糖凝集素3重組兔單抗 |
| 別 名 | CBP35; Gal-3; 35 kDa lectin; GALBP; IgE-binding protein; Laminin-binding protein; Lectin L-29; Mac-2 antigen; LGALS3; MAC2; Galectin 3; Galectin3. |
| 抗體來(lái)源 | Rabbit |
| 克隆類型 | Recombinant |
| 克 隆 號(hào) | 15E7 |
| 交叉反應(yīng) | Human,Rat |
| 產(chǎn)品應(yīng)用 | WB=1:500-2000,Flow-Cyt=1:20-50,ICC/IF=1:50-200
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 26 kDa |
| 檢測(cè)分子量 | 30 |
| 性 狀 | Liquid |
| 免 疫 原 | A synthesized peptide derived from human Galectin 3: 4-36/250 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 10mM phosphate buffered saline(pH 7.4) with 150mM sodium chloride, 0.05% BSA, 0.02% Proclin300 and 50% glycerol. |
| 保存條件 | Store at 4℃ for short term. Store at -20℃ for long term. Avoid repeated freeze/thaw cycles. |
| 注意事項(xiàng) | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
Galactose-specific lectin which binds IgE. May mediate with the alpha-3, beta-1 integrin the stimulation by CSPG4 of endothelial cells migration. Together with DMBT1, required for terminal differentiation of columnar epithelial cells during early embryogenesis. SWISS: P17931 Gene ID: 3958 Galectin-3是Galectin（半乳凝素）家族的一員，能識(shí)別糖蛋白和糖脂的特異性低聚糖結(jié)構(gòu)，參與多種生理和病理過(guò)程，包括細(xì)胞生長(zhǎng)和凋亡、細(xì)胞黏附、新生血管形成和腫瘤浸潤(rùn)與轉(zhuǎn)移等。Galectin-3在腫瘤的發(fā)生、發(fā)展及轉(zhuǎn)移中起重要作用。 Galectin-3在某些腫瘤組織中高表達(dá)，其在不同類型腫瘤，如結(jié)直腸癌、胃癌、胰腺癌、甲狀腺癌及肺癌等患者中的高表達(dá)水平，與低生存、腫瘤復(fù)發(fā)、預(yù)后差及對(duì)化療藥物敏感性降低相關(guān)對(duì)于某些腫瘤，Galectin-3有可能成為一個(gè)有價(jià)值的診斷標(biāo)志和治療靶點(diǎn)。 |
| 產(chǎn)品圖片 |
25 ug total protein per lane of various lysates (see on figure) probed with Galectin 3 monoclonal antibody, unconjugated (bsm-62883R) at 1:2000 dilution and 4°C overnight incubation. Followed by conjugated secondary antibody incubation at r.t. for 60 min.
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