| 產(chǎn)品編號 |
bs-1550R-PE-Cy5 |
| 英文名稱 |
Rabbit Anti-NCX1/PE-Cy5 Conjugated antibody
|
| 中文名稱 |
PE-Cy5標記的鈉鈣交換蛋白1抗體 |
| 別 名 |
Na+/Ca2+exchanger 1; CNC; DKFZp779F0871; MGC119581; FLJ37694; FLJ43417; Na+/Ca2+ exchange protein 1; Na+/Ca2+ exchanger; NCX 1; NCX; SLC8A1; SLC8A1 protein; Sodium Calcium Exchanger; Sodium/calcium exchanger 1; Solute carrier family 8 member 1; NAC1_HUMAN. |
| 規(guī)格價格 |
100ul/2980元
購買 大包裝/詢價 |
| 說 明 書 |
100ul
|
| 研究領(lǐng)域 |
腫瘤 免疫學 轉(zhuǎn)運蛋白 |
| 抗體來源 |
Rabbit |
| 克隆類型 |
Polyclonal |
| 交叉反應 |
Human, Rat,
(predicted: Mouse, Chicken, Dog, Pig, Cow, Horse, Sheep, Guinea Pig, G)
|
| 產(chǎn)品應用 |
IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 |
106kDa |
| 性 狀 |
Lyophilized or Liquid |
| 濃 度 |
1mg/ml |
| 免 疫 原 |
KLH conjugated synthetic peptide derived from human NCX1 |
| 亞 型 |
IgG |
| 純化方法 |
affinity purified by Protein A |
| 儲 存 液 |
0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存條件 |
Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 產(chǎn)品介紹 |
background:
In cardiac myocytes, Ca(2+) concentrations alternate between high levels during contraction and low levels during relaxation. The increase in Ca(2+) concentration during contraction is primarily due to release of Ca(2+) from intracellular stores. However, some Ca(2+) also enters the cell through the sarcolemma(plasma membrane). During relaxation, Ca(2+) is sequestered within the intracellular stores. To prevent overloading of intracellular stores, the Ca(2+) that entered across the sarcolemma must be extruded from the cell. The Na(+)-Ca(2+) exchanger is the primary mechanism by which the Ca(2+) is extruded from the cell during relaxation. In the heart, the exchanger may play a key role in digitalis action. The exchanger is the dominant mechanism in returning the cardiac myocyte to its resting state following excitation.[supplied by OMIM].
Subcellular Location:
Cell membrane.
Tissue Specificity:
Expressed in cardiac sarcolemma, brain, kidney, liver, pancreas, skeletal muscle, placenta and lung.
Similarity:
Belongs to the sodium/potassium/calcium exchanger family. SLC8 subfamily. Contains 2 Calx-beta domains.
Database links:
Entrez Gene: 6546 Human
Entrez Gene: 20541 Mouse
Entrez Gene: 100328570 Rabbit
Entrez Gene: 29715 Rat
Omim: 182305 Human
SwissProt: P23685 Dog
SwissProt: P48766 Guinea pig
SwissProt: P32418 Human
SwissProt: P70414 Mouse
SwissProt: Q01728 Rat
Unigene: 31961 Human
Unigene: 468274 Human
Unigene: 728911 Human
Unigene: 265834 Mouse
Unigene: 118972 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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