| 產(chǎn)品編號 |
bs-23149R-BF594 |
| 英文名稱 |
Rabbit Anti-PACAP receptor/BF594 Conjugated antibody
|
| 中文名稱 |
BF594標記的腺苷酸環(huán)化酶激活肽受體1抗體 |
| 別 名 |
ADCYAP1 R1; ADCYAP1R 1; PACAP-R1; adenylate cyclase activating polypeptide 1 (pituitary) receptor type 1; PAC 1; PAC1; PAC1R; PACAP R 1; PACAP1 R; PACAPR; PACAPRI; Pituitary adenylate cyclase activating polypeptide 1 receptor type I Hiphop; Pituitary adenylate cyclase activating polypeptide receptor; Pituitary adenylate cyclase activating polypeptide type I receptor precursor; PACR_HUMAN. |
| 規(guī)格價格 |
100ul/2980元
購買 大包裝/詢價 |
| 說 明 書 |
100ul
|
| 研究領域 |
細胞生物 免疫學 神經(jīng)生物學 細胞膜受體 G蛋白偶聯(lián)受體 |
| 抗體來源 |
Rabbit |
| 克隆類型 |
Polyclonal |
| 交叉反應 |
(predicted: Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Sheep, )
|
| 產(chǎn)品應用 |
ICC=1:50-200 IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 |
51kDa |
| 性 狀 |
Lyophilized or Liquid |
| 濃 度 |
1mg/ml |
| 免 疫 原 |
KLH conjugated synthetic peptide derived from human PACAP receptor |
| 亞 型 |
IgG |
| 純化方法 |
affinity purified by Protein A |
| 儲 存 液 |
0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存條件 |
Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 產(chǎn)品介紹 |
background:
Pituitary adenylate cyclase-activating polypeptide (PACAP) is a neuropeptide belonging to the vasoactive intestinal polypeptide/glucagon/ secretin family. It is widely distributed in the body, and a variety of biological actions have been reported. Recent studies have shown that there is a family of PACAP receptors (PACAPRs), and two members of this family have been identified. This is a receptor for PACAP-27 and PACAP-38. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. May regulate the release of adrenocorticotropin, luteinizing hormone, growth hormone, prolactin, epinephrine, and catecholamine. May play a role in spermatogenesis and sperm motility. Causes smooth muscle relaxation and secretion in the gastrointestinal tract (By similarity). Belongs to the G-protein coupled receptor 2 family.
Function:
This is a receptor for PACAP-27 and PACAP-38. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. May regulate the release of adrenocorticotropin, luteinizing hormone, growth hormone, prolactin, epinephrine, and catecholamine. May play a role in spermatogenesis and sperm motility. Causes smooth muscle relaxation and secretion in the gastrointestinal tract.
Subunit:
Interacts (via N-terminal extracellular domain) with ADCYAP1.
Subcellular Location:
Cell membrane; Multi-pass membrane protein.
Tissue Specificity:
Most abundant in the brain, low expression in the lung, liver, thymus, spleen, pancreas and placenta.
Similarity:
Belongs to the G-protein coupled receptor 2 family.
Database links:
Entrez Gene: 117 Human
Entrez Gene: 319095 Cow
Entrez Gene: 11517 Mouse
Entrez Gene: 24167 Rat
Omim: 102981 Human
SwissProt: Q29627 Cow
SwissProt: P41586 Human
SwissProt: P70205 Mouse
SwissProt: P32215 Rat
Unigene: 377783 Human
Unigene: 44245 Mouse
Unigene: 88408 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
生長因子和激素（ Growth Factor and Hormones）
PACAP 受體分為兩個亞型，PACAP-1型受體對PACAP是特異性的，與PACAP的親和力比VIP高100-1000倍，PACAP-II型受體與PACAP和VIP的親和力相似，對二者無選擇性。此抗體即為前者。
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